The Quattro Premier is a compact, bench top, triple quadrupole MS/MS mass spectrometer configured for API LC-MS/MS and comprises of the following components:
Z-Flow API SOURCE
Atmospheric pressure ionisation (API) HPLC interface that includes the source and spraying elements. These are visible through the windowed source enclosure and the source elements may be easily removed for cleaning, without breaking vacuum. The nebulized spray is positioned vertically, with the sprayer orientated orthogonally and positioned off axis for maximum source longevity and analyser protection against ‘dirty’ samples. Positive and negative capability is included. All source voltages are under data system control.
SOURCE ION TRANSFER OPTICS
A high efficiency, travelling wave device serves as the ion guide between the source and the analyser.
QUADRUPOLE ANALYSER
A high performance tandem quadrupole analyser with inter-element beam focusing and a mass range of 2-3000 amu.
The analyser includes the following:
- Two high resolution, quadrupole analysers (MS1/MS2).
- Pre-filters to maximise resolution and transmission especially at high mass and also to eliminate main filter cleaning.
- Two solid state RF generators with 3KV peak to peak maximum output.
COLLISION CELL
A high efficiency, travelling wave device with beam focusing at cell entry/exit. The collision cell gas pressure is directly monitored in the range 1×10-4 to 1 mbar. Collision gas introduction, pump out and regulation are computer controlled.
DETECTOR
An off-axis Dynolite photomultiplier detector positioned after the second mass analyser. A high voltage conversion dynode and a high voltage phosphor are positioned at 90° to the analyser for the elimination of neutral noise. The photomultiplier is enclosed in its own vacuum envelope for long life. The detector operates in both positive and negative ion modes and can switch rapidly under MassLynx digital control.
VACUUM SYSTEM
Clean, differentially pumped, automated vacuum system comprising:
- Three air-cooled Edwards EXT255H turbomolecular pumps evacuating the source & analyser, eliminating the need for water chillers.
- One E2M28 rotary pump (or an optional XDS35I Scroll pump) for backing of the turbo pumps.
Vacuum read backs and system vent/pump cycles are digitally monitored and controlled, to provide total software control and ensure fail-safe operation in the event of power failure. A turbo pump is fitted with an electromagnetic vent valve. A Pirani gauge is fitted to the collision cell for gas pressure monitoring. A Penning gauge is fitted to the analyser to monitor the vacuum.
ADDITIONAL FEATURES
- Electronic mass flow control devices for the MassLynx regulation of desolvation gas, cone gas and collision gas.
- Electronic injector valve controllable from the instrument software or the front panel. The injector valve can be also be programmed from Masslynx to function as a divert valve.
- An integral syringe pump controlled from Masslynx with a flow rate of 1-1000 microlitres/ minute, capable of accepting a wide variety of syringe sizes.
- Dimensions are: 48cm (width), 70.5cm (height), 89.4cm (depth)
- A maximum scan speed of 5000amu/sec.
- Mass drift 0.2Da in 24hrs.
- The linearity of response relative to sample concentration, for a specified compound, is 5 orders of magnitude from the limit of detection
Software licences are the responsibility of the customer.
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