Depending on the noise level, we would usually recommend shutting down the MS immediately to avoid catastrophic failure of the pump. We can arrange for an exchange pump at a …
My Turbo Pump is louder than normal – what should I do? Read More »
Start in Pos Ion mode and use compound such as PPG’s to monitor MI scans across the range of masses that reflect the region you typically work within. Aquire run …
Please check for any leaks in and around the pump and make sure the oil is still at a suitable level, depending on what type of pump you can normally …
My Backing pump seems to be making a louder noise than normal? Read More »
For Electrospray MS in the positive mode, it is typical to detect (M+H)+ and relevant fragment ions, whilst with the negative ion mode, (M-H)+ molecular ions are normally observed. It …
What kinds of adducts are commonly observed in ES–MS? Read More »
First it is best to understand the differences in the techniques. ESI ionisation occurs in the mobile phase with the addition of either a basic or acidic modifier to promote …
Providion recommend that the instrument calibration and resolution optimisation should be performed every 6 months especially if the instrument is being used frequently. If there isn’t the ability in-house for …
Build up of deposits and contamination can interfere with MS performance leading to loss in performance and sensitivity. Regular cleaning of the ion source as per manufacturer recommended guidelines is …
How do I know when to clean my mass spectrometer? Read More »
When it comes to laboratory relocation nothing is more stressful than the nail-biting process of packing up and re-installing high-end instrumentation, such as analytical chromatography and mass spectrometers. Let’s …
It’s well known that LC-MS (Liquid Chromatography Mass Spectrometry) is a highly powerful tool for analytical detection of compounds and employed in a wide variety of industries. From environmental labs …
